Brain on Fire: My Month of Madness

CHAPTER 1: BEDBUG BLUES

1 those suffering from parasitosis: Nancy C. Hinkle, “Delusory Parasitosis,” American Entomologist 46, no. 1 (2000): 17–25, http://www.entuga.edu/pubs/delusory.pdf (accessed August 2, 2011).

2 releasing millions of virus particles: Vincent Racaniello, “Virology 101,” Virology Blog: About Viruses and Diseases, http://www.virology.ws/virology-101/ (accessed March 1, 2011). Robert Kulwich, “Flu Attack! How the Virus Invades Your Body,” NPR.org [blog], October 23, 2009 (accessed March 1, 2011).

CHAPTER 4: THE WRESTLER

3 “I used to try to forget about you”: Robert D. Siegel, The Wrestler, directed by Darren Aronofsky, Fox Searchlight, 2008.

CHAPTER 7: ON THE ROAD AGAIN

4 “That’s nice to have at seven in the morning”: “Basking in Basque Country,” Spain… on the Road Again, PBS, New York, original broadcast date October 18, 2008.

CHAPTER 8: OUT-OF-BODY EXPERIENCE

5 complex partial seizures: Epilepsy Foundation, “Temporal Lobe Epilepsy,” Epilepsyfoundation.org, http://www.epilepsyfoundation.org/aboutepilepsy/syndromes/temporallobeepilepsy.cfm (accessed March 1, 2011). Temkin Owsei, The Falling Sickness: A History of Epilepsy from the Greeks to the Beginnings of Modern Neurology (Baltimore: Johns Hopkins University Press, 1971).

6 range from a “Christmas morning”: Alice W. Flaherty, The Midnight Disease: The Drive to Write, Writer’s Block and the Creative Brain (New York: Houghton Mifflin, 2004), 27.

7 religious experiences: Akira Ogata and Taihei Miyakawa, “Religious Experience in Epileptic Patients with Focus on Ictal-Related Episodes,” Psychiatry and Clinical Neurosciences 52 (1998): 321–325, http://onlinelibrary.wiley.com/doi/10.1046/j.1440–1819.1998.00397.x/pdf.

8 A small subset of those with temporal lobe epilepsy: Shahar Arzy, Gregor Thut, Christine Mohr, Christoph M. Michel, and Olaf Blanke, “Neural Basis of Embodiment: Distinct Contributions of Temporoparietal Junction and Extrastriate Body Area,” Journal of Neuroscience 26 (2006): 8074–8081.

CHAPTER 9: A TOUCH OF MADNESS

9 best places to live in America by Money magazine: CNN Money, “Best Places to Live: 2005,” Money.CNN.com, http://money.cnn.com/magazines/moneymag/bplive/2005/snapshots/30683.html (accessed Thursday, April 12, 2012).

10 “a brain disorder that causes unusual shifts in moods”: National Institutes of Health, “Bipolar Disorder,” NIH.gov, http://www.nimh.nih.gov/health/publications/bipolar-disorder/nimh-bipolar-adults.pdf (accessed March 14, 2009).

11 Jim Carrey, Winston Churchill, Mark Twain, Vivien Leigh, Ludwig van Beethoven, Tim Burton: Bipolar Disorder Today, “Famous People with Bipolar Disorder,” Mental-Health-Today.com, http://www.mental-health-today.com/bp/famous_people.htm (accessed March 14, 2009).

CHAPTER 15: THE CAPGRAS DELUSION

12 her husband had become a “double”: Orin Devinsky, “Delusional Misidentifications and Duplications,” Neurology 72 (2009): 80–87.

13 revealed that Capgras delusions: Jad Abumrad and Robert Krulwich, “Seeing Imposters: When Loved Ones Suddenly Aren’t,” NPR, March 30, 2010, http://www.npr.org/templates/story/story.php?storyId=124745692 (accessed May 4, 2011). V. S. Ramachandran and Sandra Blakeslee, Phantoms in the Brain: Probing the Mysteries of the Human Mind (New York: Morrow, 1998), 161–171.

CHAPTER 16: POSTICTAL FURY

14 twelve hours or as long as three months: Orin Devinsky, “Postictal Psychosis: Common, Dangerous, and Treatable,” Epilepsy Currents, February 26, 2008, 31–34. Kenneth Alper et al., “Premorbid Psychiatric Risk Factors for Postictal Psychosis,” Journal of Neuropsychiatry and Clinical Neuroscience 13 (2001): 492–499. Akira Ogata and Taihei Miyakawa, “Religious Experience in Epileptic Patients with Focus on Ictal-Related Episodes,” Psychiatry and Clinical Neuroscience 52 (1998): 321–325.

15 “postictal fury”: S. J. Logsdail and B. K. Toone, “Post-Ictal Psychoses: A Clinical and Phenomenological Description,” British Journal of Psychiatry 152 (1988): 246–252.

16 A quarter of psychotic people: Michael Trimble, Andy Kanner, and Bettina Schmitz, “Postictal Psychosis,” Epilepsy and Behavior 19 (2010): 159–161.

CHAPTER 17: MULTIPLE PERSONALITY DISORDER

17 I was within the age range for psychotic breaks: The New York Times Health Guide, “Schizophrenia,” Health.nytimes.com, http://health.nytimes.com/health/guides/disease/schizophrenia/risk-factors.html (accessed February 20, 2010).

18 dissociative identity disorder (DID): “Dissociative Identity Disorder,” in American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders—IV (Text Revision) (Washington, D.C.: American Psychiatric Association, 2 000), 526–529.

19 On of a scale from 1 (most dire cases) to 100: “Bipolar Disorder,” in ibid.

CHAPTER 18: BREAKING NEWS

20 “Like a bolt from the blue”: P. A. Pichot, “A Comparison of Different National Concepts of Schizoaffective Psychosis,” in Schizoaffective Psychoses (Berlin: Springer-Verlag, 1986), 8–16. A. Marneros and M. T. Tsuang, “Schizoaffective Questions and Directions,” in Schizoaffective Psychoses (Berlin: Springer-Verlag, 1986).

21 “uninterrupted period of illness during”: American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders—IV (Text Revision) (Washington, D.C.: American Psychiatric Association, 2000), 319–323.

CHAPTER 21: DEATH WITH INTERRUPTIONS

22 In 1933, a bicycle struck seven-year-old Henry Gustav Molaison: Luke Dittrich, “The Brain That Changed Everything,” Esquire.com, October 5, 2010, www.esquire.com/features/henry-molaison-brain-1110 (accessed May 8, 2011). “Histopathological Examination of the Brain of Amnesiac Patient H.M.,” Brain Observatory, August 18, 2010, http://thebrainobservatory.ucsd.edu/content/histopathological-examination-brain-amnesic-patient-hm (accessed May 8, 2011). William Beecher Scoville and Brenda Milner, “Loss of Recent Memory after Bilateral Hippocampal Lesions,” Journal of Neurology, Neurosurgery and Psychiatry 20 (1957): 11–21. Benedict Carey, “H.M., an Unforgettable Amnesiac, Dies at 82,” New York Times, December 5, 2008, http://www.nytimes.com/2008/12/05/us/05hm.html?pagewanted=all (accessed May 8, 2011).

23 “Clive was under the constant impression”: Deborah Wearing, Forever Today: A True Story of Lost Memory and Never-Ending Love (London: Corgi, 2006).

24 “I haven’t heard anything”: Oliver Sacks, “The Abyss: Music and Amnesia,” New Yorker, September 24, 2007, http://www.newyorker.com/reporting/2007/09/24/070924fa_fact_sacks (accessed September 13, 2011).

CHAPTER 22: A BEAUTIFUL MESS

25 At the top of the spinal cord and at the underside of the brain: Michael O’Shea, The Brain: A Very Short Introduction (Oxford: Oxford University Press, 2005). Rita Carter, Susan Aldridge, Martyn Page, and Steve Parker, The Human Brain Book (London: DK Adult, 2009). Stephen G. Waxman, Clinical Neuroanatomy, Twenty-Sixth Edition (New York: McGraw Hill, 2010).

26 “The brain is a monstrous, beautiful mess”: William F. Allman, Apprentices of Wonder: Inside the Neural Network Revolution (New York: Bantam, 1989), 3.

CHAPTER 24: IVIG

27 IVIG is made up of serum antibodies: Falk Nimmerjahn and Jeffrey V. Ravetch, “The Anti-Inflammatory Activity of IgG: The Intravenous IgG Paradox,” Journal of Experimental Medicine 204 (2007): 11–15. Arturo Casadevall, Ekaterina Dadachova, and Liise-Anne Pirofski, “Passive Antibody Therapy for Infectious Diseases,” Nature Reviews Microbiology 2 (2004): 695–703. Noah S. Scheinfeld, “Intravenous Immunoglobulin,” Medscape Reference, http://emedicine.medscape.com/article/210367-overview (accessed May 8, 2011).

28 Antibodies are created by the body’s immune system: John M. Dwyer, The Body at War: The Story of Our Immune System (Sydney, Australia: Allen & Unwin, 1994), 28–52. S. Jane Flint, Lynn W. Enquist, Vincent R. Racaniello, and A. M. Skalka, Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses, Third Edition (Washington, D.C.: American Society of Microbiology, 2009), 86–130. Noel R. Rose and Ian R. Mackay, eds., The Autoimmune Diseases, Fourth Edition (St. Louis, Mo.: Elsevier, 2006). Lauren Sompayrac, How the Immune System Works, Third Edition (Oxford: Blackwell, 2008). Massoud Mahmoudi, Immunology Made Ridiculously Simple (Miami: Med Master, 2009). Robert G. Lahita, Women and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself (New York: Morrow, 2004).

29 ten days versus the innate system’s minutes or hours: Vincent Racaniello, “Innate Immune Defenses,” Virology.ws, http://www.virology.ws/2009/06/03/innate-immune-defenses (accessed March 11, 2010). Vincent Racaniello, “Adaptive Immune Defenses,” Virology.ws, http://www.virology.ws/2009/07/03/adaptive-immune-defenses (accessed March 11, 2010).

30 collateral damage of these internal battles: Lauren Sompayrac, How the Immune System Works, Third Edition (Oxford: Blackwell, 2008). Massoud Mahmoudi, Immunology Made Ridiculously Simple (Miami: Med Master, 2009). Robert G. Lahita, Women and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself (New York: Morrow, 2004).

31 plasma cells that create antibodies: John M. Dwyer, The Body at War: The Story of Our Immune System (Sydney, Australia: Allen & Unwin, 1994), 28–52. S. Jane Flint, Lynn W. Enquist, Vincent R. Racaniello, and A. M. Skalka, Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses, Third Edition (Washington, D.C.: American Society of Microbiology, 2009), 86–130. Noel R. Rose and Ian R. Mackay, eds., The Autoimmune Diseases: Fourth Edition (St. Louis: Elsevier, 2006). Lauren Sompayrac, How the Immune System Works, Third Edition (Oxford: Blackwell, 2008). Massoud Mahmoudi, Immunology Made Ridiculously Simple (Miami: Med Master, 2009). Robert G. Lahita, Women and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself (New York: Morrow, 2004).

32 WIRED ’N MIRED: Brendan T. Carroll, Christopher Thomas, Kameshwari Jayanti, John M. Hawkins, and Carrie Burbage, “Treating Persistent Catatonia When Benzodiazepines Fail,” Current Psychiatry 4 (2005): 59.

CHAPTER 26: THE CLOCK

33 Although developed in the mid-1950s: Janus Kremer, “Clock Drawing in Dementia: A Critical Review,” Revista Neurologica Argentina 27 (2002): 223–227.

34 The healthy brain enables vision: Francesco Pavani, Elisabetta Ladavas, and Jon Driver, “Auditory and Multisensory Aspects of Visuospatial Neglect,” Trends in Cognitive Sciences 7 (2008): 407–414. V. S. Ramachandran and Sandra Blakeslee, Phantoms in the Brain: Probing the Mysteries of the Human Mind (New York: Morrow, 1998), 115–125. V. S. Ramachandran, The Tell-Tale Brain: A Neuroscientist’s Quest for What Makes Us Human (New York: Norton, 2011), 1–21. Michael O’Shea, The Brain: A Very Short Introduction (Oxford: Oxford University Press, 2005). Rita Carter, Susan Aldridge, Martyn Page, and Steve Parker, The Human Brain Book (London: DK Adult, 2009). Stephen G. Waxman, Clinical Neuroanatomy, Twenty-Sixth Edition (New York: McGraw-Hill, 2010).

35 visual indifference: V. S. Ramachandran and Sandra Blakeslee, Phantoms in the Brain: Probing the Mysteries of the Human Mind (New York: Morrow, 1998), 118.

CHAPTER 28: SHADOWBOXER

36 The blood-brain barrier (BBB): Davis Lab, “History of the Blood Brain Barrier,” University of Arizona, http://davislab.med.arizona.edu/content/history-blood-brain-barrier (accessed April 23, 2011).

37 These steroids, called corticosteroids: Julia C. Buckingham, “Glucocorticoids: Exemplars of Multi-Tasking,” British Journal of Pharmacology 147 (2006): S258—S268. Mayo Clinic Staff, “Prednisone and Other Corticosteroids: Balance the Risks and Benefits,” MayoClinic.com, http://www.mayoclinic.com/health/steriods/HQ01431 (accessed May 8, 2011). Peter J. Barnes, “How Corticosteroids Control Inflammation: Quintiles Prize Lecture 2005,” British Journal of Pharmacology 148 (2006): 245–254.

CHAPTER 29: DALMAU’S DISEASE

38 paraneoplastic syndrome: National Institute of Neurological Disorders and Stroke, “NINDS Paraneoplastic Syndrome Information Page,” National Institutes of Health, http://www.ninds.nih.gov/disorders/paraneoplastic/paraneoplastic.htm (accessed March 2, 2011). Roberta Vitaliani, Warren Mason, Beau Ances, Theodore Zwerdling, Zhilong Jiang, and Josep Dalmau, “Paraneoplastic Encephalitis, Psychiatric Symptoms, and Hypoventilation in Ovarian Teratomas,” Annals of Neurology 58 (2005): 594–604.

39 NMDA (N-methyl-D-aspartate acid) receptors are vital to learning: David J. Linden, The Accidental Mind: How Brain Evolution Has Given Us Love, Memory, Dreams and God (Cambridge, Mass.: Belknap Press of Harvard University Press, 2007), 107–144. Fei Li and Joe Z. Tsien, “Memory and NMDA Receptors,” New England Journal of Medicine 361 (2009): 302–303.

40 “knockout mice” without NMDA receptors: Wade Roush, “New Knockout Mice Point to Molecular Basis of Memory,” Science 275 (1997), www.bio.davidson.edu/courses/molbio/restricted/knockbrain/BrainKO.html (accessed May 18, 2011). Zhenzhong Cui, Huimin Wang, Yuansheng Tan, Kimberly A. Zaia, Shuqin Zhang, and Joe Z. Tsein, “Inducible and Reversible NR1 Knockout Reveals Crucial Role of the NMDA Receptor in Preserving Remote Memories in the Brain,” Neuron 41 (2004): 781–793. Laure Rondi-Reig, Megan Libbey, Howard Eichenbaum, and Susumu Tonegawa, “CA1-Specific NMDA Receptor Knockout Mice Are Deficient in Solving Nonspatial Transverse Patterning Task,” Proceedings of the National Academy of Sciences 98 (2001): 3543–3548.

41 This second article identified twelve women: Josep Dalmau et al., “Paraneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma,” Annals of Neurology 61 (2007): 25–36.

CHAPTER 31: THE BIG REVEAL

42 For 70 percent of patients, the disorder begins innocuously, with normal flulike symptoms: Josep Dalmau et al., “Clinical Experience and Laboratory Investigations in Patients with Anti-NMDAR Encephalitis,” Lancet Neurology 10 (2011): 63–74.

43 75 percent of patients recover fully or maintain only mild side effects: Josep Dalmau et al., “Clinical Experience and Laboratory Investigations in Patients with Anti-NMDAR Encephalitis,” Lancet Neurology 10 (2011): 63–74.

44 late 1800s, a German doctor christened it “teratoma”: Elizabeth Svoboda, “Monster Tumors Show Scientific Potential in War against Cancer,” New York Times, June 6, 2006, http://www.nytimes.com/2006/06/06/health/06tera.html (accessed May 1, 2011).

CHAPTER 33: HOMECOMING

45 stages of recovery often occur in reverse order: Josep Dalmau et al., “Clinical Experience and Laboratory Investigations in Patients with Anti-NMDAR Encephalitis,” Lancet Neurology 10 (2011): 63–74.

CHAPTER 34: CALIFORNIA DREAMIN’

46 Swedish dairy cream separator created in the late 1800s: T. J. Hamblin, “Apheresis Therapy: Spin-Drying the Blood,” British Medical Journal 285 (1982): 1136–1137. Dianne M. Cearlock and David Gerteisen, “Therapeutic Plasmapheresis for Autoimmune Diseases: Advances and Outcomes,” Medical Laboratory Observer, November 2010, http://www.mlo-online.com/articles/nov00.pdf (accessed May 2011).

CHAPTER 39: WITHIN NORMAL LIMITS

47 Often those with neurological issues cannot readily identify: Rhawn Joseph, Neuropsychiatry, Neuropsychology, Clinical Neuroscience (Orlando, Fla.: Academic Press, 2000), http://brainmind.com/Agnosia.html.

CHAPTER 40: UMBRELLA

48 frontal lobes are largely responsible for complex executive functions: Michael O’Shea, The Brain: A Very Short Introduction (Oxford: Oxford University Press, 2005). Rita Carter, Susan Aldridge, Martyn Page, and Steve Parker, The Human Brain Book (London: DK Adult, 2009).

49 “ice pick” lobotomy: “My Lobotomy: Henry Dully’s Journey,” All Things Considered, NPR.org, November 16, 2005, http://www.npr.org/templates/story/story.php?storyId=5014080 (accessed May 13, 2011). Shanna Freeman, “How Lobotomies Work,” HowStuffWorks.com, http://science.howstuffworks.com/environmental/life/human-biology/lobotomy3.htm (accessed May 13, 2011).

CHAPTER 43: NDMA

50 New York Times Magazine “Diagnosis” column: Lisa Sanders, “Diagnosis: Brain Drain,” New York Times Magazine, November 9, 2008, http://query.nytimes.com/gst/fullpage.html?res=9C05E7DA1F3BF93AA35752C1A96E9C8B63.

CHAPTER 47: THE EXORCIST

51 Dr. Guillaume Sébire noticed an unusual pattern: Guillaume Sébire et al., “Coma Associated with Intense Bursts of Abnormal Movements and Long-Lasting Cognitive Disturbances: An Acute Encephalopathy of Obscure Origin,” Journal of Pediatrics 121 (1992): 845–851.

52 1981 by Robert Delong and colleagues, described: Robert G. Delong et al., “Acquired Reversible Autistic Syndrome in Acute Encephalopathic Illness in Children,” Child Neurology 38 (1981): 191–194.

53 40 percent of patients diagnosed with this disease are children: Josep Dalmau et al., “Clinical Experience and Laboratory Investigations in Patients with Anti-NMDAR Encephalitis,” Lancet Neurology 10 (2011): 63–74.

54 thirteen-year-old girl from Tennessee displayed: Emily Bregel, “Chattanooga: Teen Has ‘Miraculous’ Recovery from an Unusual Tumor Disorder,” TimesFreePress.com, June 11, 2009, http://timesfreepress.com/news/2009/jun/11/chattanooga-teen-has-miraculous-recovery-unusual-t/?local.

55 what is known as echolalia: Guillaume Sébire, “In Search of Lost Time: From Demonic Possession to Anti-NMDAR Encephalitis,” Annals of Neurology 66 (2009): 11–8. Nicole R. Florance and Josep Dalmau, “Reply to: In Search of Lost Time: From ‘Demonic Possession to Anti-NMDAR Encephalitis,’” Annals of Neurology 67 (2010): 142–143.

56 a nineteen-year-old woman: Souhel Najjar, D. Pearlman, D. Zagzag, J. Golfinos, and O. Devinsky, “Glutamic Acid Decarboxylase Autoantibody Syndrome Presenting as Schizophrenia,” Neurologist 18 (2012): 88–91.

57 the rate of misdiagnoses: David Leonhardt, “Why Doctors So Often Get It Wrong,” New York Times, February 22, 2006, http://www.nytimes.com/2006/02/22/business/22leonhardt.html.

CHAPTER 48: SURVIVOR’S GUILT

58 one hundred different kinds of autoimmune diseases: American Autoimmune Related Diseases Association and National Coalition of Autoimmune Patient Groups, “The Cost Burden of Autoimmune Disease: The Latest Front in the War on Healthcare Spending” (Eastpointe, Mich.: American Autoimmune Related Diseases Association, 2011). Autoimmune Diseases Coordinating Committee, “Autoimmune Diseases Research” (Bethesda, Md.: National Institutes of Health, March 2005).

59 20 to 30 percent of survivors develop it: Gwen Adshead, “Psychological Therapies for Post-Traumatic Stress Disorder,” British Journal of Psychiatry 177 (2000): 144–148.

CHAPTER 50: ECSTATIC

60 relapses happen in about 20 percent of cases: Josep Dalmau et al., “Clinical Experience and Laboratory Investigations in Patients with Anti-NMDAR Encephalitis,” Lancet Neurology 10 (2011): 63–74.

CHAPTER 51: FLIGHT RISK?

61 In 2010, a Cambridge University study: Hannah L. Morgan, Danielle C. Turner, Philip R. Corlett, Anthony R. Absalom, Ram Adapa, Fernando S. Arana, Jennifer Pigott, Jenny Gardner, Jessica Everitt, Patrick Haggard, and Paul C. Fletcher, “Exploring the Impact of Ketamine on the Experience of Illusory Body Ownership,” Biological Psychiatry 69, no. 1 (2011): 35–41.

62 self-monitoring theory: Sharon Begley, “The Schizophrenic Mind,” Newsweek, March 11, 2002, www.newsweek.com/2002/03/10/the-schizophrenic-mind.print.html (accessed April 21, 2011). Dominic H. Ffytche, “The Hodology of a Hallucinations,” Cortex 44 (2008): 1067–1083.

63 generation effect: Philip D. Harvey et al., “Cortical and Subcortical Cognitive Deficits in Schizophrenia: Convergence of Classifications Based on Language and Memory Skill Areas,” Journal of Clinical and Experimental Neuropsychology 24 (2002): 55–66. Carol A. Tamminga, Ana D. Stan, and Anthony D. Wagner, “The Hippocampal Formation in Schizophrenia,” American Journal of Psychiatry 167 (2010): 1178–1193. Daphna Shohamy, Perry Mihalakos, Ronald Chin, Binu Thomas, Anthony D. Wagner, and Carol Tamminga, “Learning and Generalization in Schizophrenia: Effects of Disease and Antipsychotic Drug Treatment,” Biological Psychiatry 67 (2010): 926–932.

64 amygdala, an almond-shaped structure situated atop the hippocampus: Michael O’Shea, The Brain: A Very Short Introduction (Oxford: Oxford University Press, 2005). Rita Carter, Susan Aldridge, Martyn Page, and Steve Parker, The Human Brain Book (London: DK Adult, 2009). Elizabeth A. Phelps and Tali Sharot, “How (and Why) Emotion Enhances Subjective Sense of Recollection,” Current Directions in Psychological Sciences 17 (2008): 147–152, http://www.psych.nyu.edu/phelpslab/papers/08_CDPS_V17No2_147.pdf. Joseph E. LeDoux, “Emotion Circuits in the Brain,” Annual Reviews of Neuroscience 23 (2000): 155–185.

65 help encode and consolidate: Jesse Rissman and Anthony D. Wagner, “Distributed Representations in Memory: Insights from Functional Brain Imaging,” Annual Review of Psychology 63 (2012): 101–128. Richard C. Mohs, “How Human Memory Works,” HowStuffWorks.com, http://science.howstuffworks.com/environmental/life/human-biology/human-memory.htm.

66 Dr. Loftus has spent a lifetime: William Saletan, “The Memory Doctor: The Future of False Memories,” Slate.com, June 4, 2010, http://www.slate.com/articles/health_and_science/the_memory_doctor/2010/06/the_memory_doctor.single.html.

67 A team of New York–based neuroscientists in 2000 demonstrated this assumption in lab rats: Greg Miller, “How Our Brains Make Memories,” Smithsonian, May 2010, http://www.smithsonianmag.com/science-nature/How-Our-Brains-Make-Memories.html. “Big Think Interview with Joseph LeDoux,” BigThink.com, June 9, 2010, http://bigthink.com/josephledoux.

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