For these and many others, see http://news.bbc.co.uk/1/hi/sci/tech/807126.stm
A useful starting point for descriptions of the symptoms of schizophrenia, its effects on patients and their families, and relevant statistics is www.schizophrenia.com
http://www.britishlivertrust.org.uk/home/the-liver.aspx
http://www.wellcome.ac.uk/News/2010/Features/WTX063605.htm
Quoted in the The Scientist Speculates, ed. Good, I.J. (1962), published by Heinemann.
Key papers from this programme of work include: Gurdon et al. (1958) Nature 182: 64–5; Gurdon (1960) J Embryol Exp Morphol. 8: 505–26; Gurdon( 1962) J Hered. 53: 5–9; Gurdon (1962) Dev Biol. 4: 256–73; Gurdon (1962) J Embryol Exp Morphol. 10: 622–40.
Waddington, C. H. (1957), The Strategy of the Genes, published by Geo Allen & Unwin.
Campbell et al. 1996 Nature 380: 64–6.
For a useful review of the state of knowledge at the time see Rao, M. (2004) Dev Biol. 275: 269–86.
Takahashi and Yamanaka (2006), Cell 126: 663–76.
Pang et al. (2011), Nature online publication May 26.
Alipio et al. (2010), Proc Natl Acad Sci. USA 107: 13426–31.
Nakagawa et al. (2008), Nat Biotechnol. 26: 101–6.
See, for example, Baharvand et al. (2010) Methods Mol Biol. 584: 425–43.
Gaspar and Thrasher (2005), Expert Opin Biol Ther. 5: 1175–82.
Lapillonne et al. (2010), Haematologica 95: 1651–9.
See http://genome.wellcome.ac.uk/doc_WTD020745.html for a wealth of useful genome-related facts and figures.
Schoenfelder et al. (2010), Nat Genet. 42: 53–61.
Kruczek and Doerfler (1982), EMBO J. 1:409–14.
Bird et al. (1985), Cell 40: 91–99.
Lewis et al. (1992), Cell 69: 905–14.
Nan et al. (1998), Nature 393: 386–9.
For a recent review of the actions of MeCP2, see Adkins and Georgel (2011), Biochem Cell Biol. 89: 1–11.
Guy et al. (2007), Science 315: 1143–7.
http://www.youtube.com/watch?v=RyAvKGmAElQ&feature=related
The most important papers from the Allis lab in 1996 were: Brownell et al. (1996), Cell 84: 843–51; Vettese-Dadey et al. (1996), EMBO J. 15: 2508–18; Kuo et al. (1996), Nature 383: 269–72.
A useful review by one of the leading researchers in the field is Kouzarides, T. (2007) Cell 128: 693–705.
Jenuwein and Allis (2001), Science 293: 1074–80.
Ng et al. (2010), Nat Genet. 42: 790–3.
Laumonnier et al. (2005), J Med Genet. 42: 780–6.
Fraga et al. (2005), Proc Natl Acad Sci. USA 102: 10604–9.
Ollikainen et al. (2010), Human Molecular Genetics 19: 4176–88.
http://www.pbs.org/wgbh/evolution/library/04/4/l_044_02.html
http://www.evolutionpages.com/Mouse%20genome%20home.htm
Gartner, K. (1990), Lab Animal 24:71–7.
Whitelaw et al. (2010), Genome Biology.
Tobi et al. (2009), HMG.
Kaminen-Ahola et al. (2010).
If you want to know more, try Arthur Koestler’s highly readable though exceptionally partisan book, The Case of the Midwife Toad.
Lumey et al. (1995), Eur J Obstet Reprod Biol. 61: 23–20.
Lumey (1998), Proceedings of the Nutrition Society 57: 129–135.
Kaati et al. (2002), EJHG 10: 682–688.
Morgan et al. (1999), Nature 23: 314–8.
Wolff et al. (1998), FASEB J 12: 949–957.
Rakyan et al. (2003), PNAS 100: 2538–2543.
World Cancer Research Fund figures http://tinyurl.com/47uosv4
www.nhs.uk
Waterland et al. (2007), FASEB J 21: 3380–3385.
Ng et al. (2010), Nature 467: 963–966.
Carone et al. (2010) Cell 143: 1084–1096.
Anway et al. (2005) Science 308: 1466–1469.
Guerrero-Bosagna et al. (2010), PLoS One: 5.
Surani, Barton and Norris (1984), Nature 308: 548–550.
Barton, Surani and Norris (1984), Nature 311: 374–376.
Surani, Barton and Norris (1987), Nature 326: 395–397.
McGrath and Solter (1984), Cell 37: 179–183.
Cattanach and Kirk (1985), Nature 315: 496–498.
Hammoud et al. (2009) Nature 460: 473–478.
Reik et al. (1987), Nature 328: 248–251.
Sapienza et al. (1987), Nature 328: 251–254.
Rakyan et al. (2003), PNAS 100: 2538–2543.
Surani, Barton and Norris (1984), Nature 308: 548–550.
Barton, Surani and Norris (1984), Nature 311: 374–376.
Surani, Barton and Norris (1987), Nature 326: 395–397.
Cattanach and Kirk (1985), Nature 315: 496–8.
De Chiara et al. (1991), Cell 64: 845–859.
Barlow et al. (1991), Nature 349: 84–87.
Reviewed in Butler (2009), Journal of Assisted Reproduction and Genetics: 477–486
Prader, A., Labhart, A. and Willi, H. (1956), Schweiz Med Wschr. 86: 1260–1261.
http://www.ncbi.nlm.nih.gov/omim/176270
Angelman, H. (1965), ‘Puppet children’: a report of three cases. Dev Med Child Neurol. 7: 681–688.
http://www.ncbi.nlm.nih.gov/omim/105830
Knoll et al.(1989), American Journal of Medical Genetics 32: 285–290.
Nicholls et al. (1989), Nature 342: 281–185.
Malcolm et al. (1991), The Lancet 337: 694–697.
Wiedemann (1964), J Genet Hum. 13: 223.
Beckwith (1969), Birth Defects 5: 188.
http://www.ncbi.nlm.nih.gov/omim/130650
Silver et al. (1953), Pediatrics 12: 368–376.
Russell (1954), Proc Royal Soc Medicine. 47: 1040–1044.
http://www.ncbi.nlm.nih.gov/omim/180860
For a useful review, see Gabory et al. (2010), BioEssays 32: 473–480.
Frost & Moore (2010), PLoS Genetics 6 e1001015.
Ohinata et al. (2005), Nature 436: 207–213.
Buiting et al. (2003), American Journal of Medical Genetics 72: 571–577.
Hammoud et al. (2009), Nature 460: 473–478.
Ooi et al. (2007), Nature 448: 714–717.
Stadtfeld et al. (2010), Nature 465: 175–81.
See Butler (2009), J Assist Reprod Genet. 26: 477–486 for a useful review.
Kono et al. (2004), Nature 428: 860–864.
Blewitt et al. (2006), PLoS Genetics 2: 399–405.
See, for example, http://www.guardian.co.uk/uk/2010/aug/04/cloned-meat-british-bulls-fsa?INTCMP=SRCH
For a recent review, see Bukulmez, O. (2009) Curr Opin Obstet Gynecol. 21: 260–4.
Jäger et al. (1990), Nature 348: 452–4.
Margarit et al. (2000), American Journal of Medical Genetics 90: 25–8.
For a good review of this, see Graves (2010), Placenta, Supplement A Trophoblast Research 24: S27–S32.
Lyon, M. F. (1961), Nature 190: 372–373.
Lyon, M. F. (1962), American Journal of Human Genetics 14: 135–148.
For a useful review, see Okamoto and Heard (2009), Chromosome Res. 17: 659–69.
McGrath and Solter (1984), Cell 37: 179–83.
Cattanach and Isaacson (1967), Genetics 57: 231–246.
Rastan and Robertson (1985), J Embryol Exp Morphol. 90: 379–88.
Brown et al. (1991), Nature 349: 38–44.
Borsani et al. (1991), Nature 351: 325–329.
Brown et al. (1992), Cell 71: 527–542.
Brockdorff et al. (1992), Cell 71: 515–526.
Borsani et al. (1991), Nature 351: 325–329.
For a good review, see Lee, J. T. (2010) Cold Spring Harbor Perspectives in Biology 2 a003749.
Lee et al. (1996), Cell 86: 83–84.
Xu et al. (2006), Science 311: 1149–52.
Lee et al. (1999), Nature Genetics 21: 400–404.
Navarro et al. (2008), Science 321: 1693–1695.
Maherali et al. (2007), Cell Stem Cell 1: 55–70.
Zonana et al. (1993), Amer J Human Genetics 52: 78–84.
http://www.ncbi.nlm.nih.gov/omim/305100
Reviewed in Pinto et al. (2010), Orphanet Journal of Rare Diseases 5: 14–23.
http://www.ncbi.nlm.nih.gov/omim/310200
Pena et al. (1987), J Neurol Sci. 79: 337–344.
Gordon (2004), Science 306: 496–499.
For a good review of this, see Graves (2010), Placenta Supplement A Trophoblast Research 24: S27–S32.
Rao et al. (1997), Nature Genetics 16: 54–63.
From Scientific Autobiography and Other Papers (1950).
Mulder et al. (1975), Cold Spring Harb Symp Quant Biol. 39: 397–400.
Ohno (1972), Brookhaven Symposia in Biology 23: 366–370.
See Orgel and Crick (1980), Nature 284: 604–607.
See Doolittle and Sapienza (1980), Nature 284: 601–603.
Mattick (2009), Annals N Y Acad Sci. 1178: 29–46.
http://genome.wellcome.ac.uk/node30006.html
http://wiki.wormbase.org/index.php/WS205
For a useful review see Qureshi et al. (2010), Brain Research 1338: 20–35.
Clark and Mattick (2011), Seminars in Cell and Developmental Biology, in press at time of publication.
Carninci et al. (2005), Science 309: 1559–1563.
Nagano et al. (2008), Science 322: 1717–1720.
Zhao et al. (2010), Molecular Cell 40: 939–953.
Garber et al. (1983), EMBO J. 2: 2027–36.
Rinn et al. (2007), Cell 129: 1311–1323.
Ørom et al. (2010), Cell 143: 46–58.
Lee et al. (1993), Cell 75: 843–854.
Wightman et al. (1993), Cell 75: 858–62.
For a good review, see Bartel (2009), Cell 136: 215–233.
Mattick, J. S. (2010), BioEssays 32: 548–552.
Chimpanzee Sequencing and Analysis Consortium (2005), Nature 437: 69–87.
Athanasiasdis et al. (2004), PLoS Biol. 2: e391.
Paz-Yaacov et al. (2010), Proc Natl Acad Sci. USA 107: 12174–9.
Melton et al. (2010), Nature 463: 621–628.
Yu et al. (2007), Science 318: 1917–20.
Marson et al. (2008), Cell 134: 521–33.
Judson et al. (2009), Nature Biotechnology 27: 459–461.
Reviewed in Pauli et al. (2011), Nature Reviews Genetics 12: 136–149.
Giraldez et al. (2006), Science 312: 75–79.
West et al. (2009), Nature 460: 909–913.
Vagin et al. (2009), Genes Dev. 23: 1749–62.
Deng and Lin (2002), Developmental Cell 2: 819–830.
Aravin et al. (2008), Molecular Cell 31: 785–799.
Kuramochi-Miyagawa et al. (2008), Genes and Development 22: 908–917.
Reviewed in Mattick et al. (2009), BioEssays 31: 51–59.
Wagner et al. (2008), Dev Cell. 14: 962–9.
Lewejohann et al. (2004), Behav Brain Res. 154: 273–89.
Clop et al. (2006), Nature Genetics 38: 813–818.
Abelson et al. (2005), Science 310: 317–320.
http://www.ncbi.nlm.nih.gov/omim/188400
Strak et al. (2008), Nature Genetics 40: 751–760.
Calin et al. (2004), Proc Nat Acad Sci. USA 101: 2999–3004.
Volinia et al. (2006), Proc Natl Acad Sci. USA 103: 2257–2261.
For a useful review see Garzon et al. (2010), Nature Reviews Drug Discovery 9: 775–789.
Melo et al. (2009), Nature Genetics 41: 365–370.
Karon et al. (1973), Blood 42: 359–65.
Constantinides et al. (1977), Nature 267: 364–366.
Taylor and Jones (1979), Cell 17: 771–779.
Jones (2011), Nature Cell Biology 13: 2.
Jones and Taylor (1980), Cell 20: 85–93.
Santi et al. (1983), Cell 33: 9–10.
Ghoshal et al. (2005), Molecular and Cellular Biology 25: 4727–4741.
Kuo et al. (2007), Cancer Research 67: 8248–8254.
For an excellent history of the development of SAHA, see Marks and Breslow (2007), Nature Biotechnology 25: 84–90.
Friend et al. (1971), Proc Natl Acad Sci. USA 68: 378–382.
Richon et al. (1996), Proc Natl Acad Sci. USA 93: 5705–5708.
Yoshida et al. (1990), Journal of Biological Chemistry 265: 17174–17179.
Richon et al. (1998), Proc Natl Acad Sci. USA 95: 3003–3007.
Herman et al. (1994), Proc Natl Acad Sci. USA 91: 9700–9704.
Esteller et al. (2000), Journal of the National Cancer Institute 92: 564–569.
Toyota et al. (1999), Proc Natl Acad Sci. USA 96: 8681–8686.
Lu et al. (2006), Oncogene 25: 230–9.
Gery et al. (2007), Clin Cancer Res. 13: 1399–404.
For a recent review of a disorder where gene therapy is proving broadly effective see Ferrua et al. (2010), Curr Opin Allergy Clin Immunol. 10: 551–6.
Kantarjian et al. (2006), Cancer 106: 1794–1803.
Silverman et al. (2002), J Clin Oncol. 20: 2429–2440.
Duvic et al. (2007), Blood 109: 31–39.
www.cancer.gov/clinicaltrials/search/results?protocolsearchid=8828355
www.lifesciencesworld.com/news/view/11080
http://www.masshightech.com/stories/2008/04/21/story1-Epigenetics-is-the-word-on-bio-investors-lips.html
Viré et al. (2006), Nature 439: 871–874.
Schlesinger et al. (2007), Nature Genetics 39: 232–236.
Shi et al. (2004), Cell 29: 119; 941–53.
Ooi et al. (2007), Nature 448: 714–717.
Bachmann et al. (2006), J Clin Oncology 24: 268–273.
Lim et al. (2010), Carcinogenesis 31: 512–20.
Kondo et al. (2008), Nature Genetics 40: 741–750.
Widschwendter et al. (2007), Nature Genetics 39: 157–158.
Taby and Issa (2010), CA Cancer J Clin. 60: 376–92.
Bernstein et al. (2006), Cell 125: 315–326.
Ohm et al. (2007), Nature Genetics 39: 237–242.
Fabbri et al. (2007), Proc Natl Acad Sci. USA 104: 15805–10.
For a recent review, see Heim et al. (2010), Dev Psychobiol. 52: 671–90.
Yehuda et al. (2001), Dev Psychopathol. 13: 733–53.
Heim et al. (2000), JAMA 284: 592–7.
Lee et al. (2005), Am J Psychiatry 162: 995–997.
Carpenter et al. (2004), Neuropsychopharm. 29: 777–784.
Weaver et al. (2004), Nature Neuroscience 7: 847–854.
Murgatroyd et al. (2009), Nature Neuroscience 12: 1559–1565.
Skene et al. (2010), Mol Cell 37: 457–68.
McGowan et al. (2009), Nature Neuroscience 12: 342–248.
http://www.who.int/mental_health/management/depression/definition/en/
Reviewed in Uchida et al. (2011), Neuron 69: 359–372.
Uchida et al. (2011), Neuron 69: 359–372.
Elliott et al. (2010), Nature Neuroscience 13: 1351–1353.
Uchida et al. (2011), Neuron 69: 359–372.
For a useful review of animal models of depression, see Nestler and Hyman (2010), Nature Neuroscience 13: 1161–1169.
Uchida et al. (2011), Neuron 69: 359–372.
Weaver et al. (2004), Nature Neuroscience 7: 847–854.
See, for example, interviews in Buchen (2010), Nature 467: 146–148.
Mayer et al. (2000), Nature 403: 501–502.
Tahiliani et al. (2009), Science 324: 30–5.
Globisch et al. (2010), PLoS One 5: e15367.
For a useful review of DNA methylation and memory formation, see Day and Sweatt (2010), Nature Neuroscience 13: 1319–1329.
Korzus et al. (2004), Neuron 42: 961–972.
Alarcón et al. (2004), Neuron 42: 947–959.
MacDonald and Roskams (2008), Dev Dyn. 237: 2256–2267.
Guan et al. (2009), Nature 459: 55–60.
Fischer et al. (2007), Nature 447: 178–182.
Im et al. (2010), Nature Neuroscience 13: 1120–1127.
Deng et al. (2010), Nature Neuroscience 13: 1128–1136.
Garfield et al. (2011), Nature 469: 534–538.
http://www.isaps.org/uploads/news_pdf/Raw_data_Survey2009.pdf
Aubert and Lansdorp (2008), Physiological Reviews 88: 557–579.
For a review of this and other surveys on public attitudes to lifespan extension, see Partridge et al. (2010), EMBO Reports 11: 735–737.
Bjornsson et al. (2008), Journal of the American Medical Association 299: 2877–2883.
Gaudet et al. (2003), Science 300: 488–492.
Eden et al. (2003), Science 300: 455.
For a useful review of changes in epigenetic modifications during ageing, see Calvanese et al. (2009), Ageing Research Reviews 8: 269–276.
Kennedy et al. (1995), Cell 80: 485–496.
Kaeberlein et al. (1999), Genes and Development 13: 2570–2580.
Dang et al. (2009), Nature 459: 802–807.
Tissenbaum and Guarente (2001), Nature 410: 227–230.
Rogina and Helfand (2004), Proceedings of the National Academy of Sciences USA 101: 15998–16003.
Michishita et al. (2008), Nature 452: 492–496.
Kawahara et al. (2009), Cell 136: 62–74.
http://www.ncbi.nlm.nih.gov/omim/277700
Michishita et al. (2008), Nature 452: 492–496.
McCay et al. (1935), Nutrition 5: 155–71.
Reviewed in Kaeberlein and Powers (2007), Ageing Research Reviews 6: 128–140.
Partridge et al. (2010), EMBO Reports 11: 735–737.
Howitz et al. (2003), Nature 425: 191–196.
Wood et al. (2004), Nature 430: 686–689.
Baur et al. (2006), Nature 444: 337–342.
Howitz et al. (2003), Nature 425: 191–196.
Beher et al. (2009), Chem Biol Drug Des. 74: 619–24.
Pacholec et al. (2010), J Biol Chem. 285: 8340–51.
For a review, see Chaturvedi et al. (2010), Chem Soc Rev. 39: 435–54.
http://www.fiercebiotech.com/story/weak-efficacy-renal-risks-force-gsk-dump-resveratrol-program/2010-12-01
McCay et al. (1935), Nutrition 5: 155–71.
For a useful review of the differences, see Chittka and Chittka (2010), PLoS Biology 8: e1000532.
For a useful summary of these processes, see Maleszka (2008), Epigenetics 3: 188–192.
Honeybee Genome Sequencing Consortium (2006), Nature 443: 931–49.
Wang et al. (2006), Science 314: 645–647.
Kucharski et al. (2008), Science 319: 1827–1830.
Lyko et al. (2010), PLos Biol. 8: e1000506.
Spannhoff et al. (2011), EMBO Reports 12: 238–243.
Lockett et al. (2010), NeuroReport 21: 812–816.
Hunt et al. (2010), Genome Biol Evol 2: 719–728.
Lyko et al. (2010), PLos Biol. 8: e1000506.
Bonasio et al. (2010), Science 329: 1068–1071
Izuta et al. (2009), Evid Based Complement Alternat Med. 6: 489–94.
For a useful review, see Dennis and Peacock (2009), J Biol 8: article 57.
For a useful summary of the epigenetic control of vernalisation, see Ahmad et al. (2010), Molecular Plant 4: 719–728.
Pien et al. (2008), Plant Cell 20: 580–588.
Sung and Amasino (2004), Nature 427: 159–164.
De Lucia et al. (2008), Proc Natl Acad Sci. USA 105: 16831–16836.
Heo and Sung (2011), Science 331: 76–79.
Pant et al. (2008), Plant J 53: 731–738.
Palauqui et al. (1997), EMBO J 16: 4738–4745
See, for example, Schubert et al. (2006), EMBO J 25: 4638–4649.
Gehring et al. (2009), Science 324: 1447–1451.
Hsieh et al. (2009), Science 324: 1451–1454
Mosher et al. (2009), Nature 460: 283–286.
Slotkin et al. (2009), Cell 136: 461–472.
Garnier et al. (2008), Epigenetics 3: 14–20.
Reviewed in Zhang et al. (2010), J Genet and Genomics 37: 1–12.
Chan et al. (2005), Nature Reviews Genetics 6: 351–360.
Cokus et al. (2008), Nature 452: 215–219.
For a recent review, see Wapstra and Warner (2010), Sex Dev. 4: 110–8.
Miller et al. (2004), Fertil Steril. 81: 954–64.
Watson, J. D. and Crick, F. H. C. (1953), Nature 171: 737–738.
Cattanach and Isaacson (1967), Genetics 57: 231–246.
For further information, see http://www.sienabiotech.com.
Mack, G. S. (2010), Nat Biotechnol. 28: 1259–66.
MRC Vitamin Study Research Group (1991), Lancet 338: 131–7.
Waterland et al. (2006), Hum Mol Genet. 15: 705–16.
Reviewed in Calvanese et al. (2009), Ageing Research Reviews 8: 268–276.
Reviewed in Guilloteau et al. (2010), Res Rev. 23: 366–84.
Palsdottir et al. (2008), PLoS Genet. June 20, 4: e1000099.
Abstract from Palsdottir et al. (2010), Wellcome Trust Conference on Signalling to Chromatin Hinxton UK
See for example Okabe et al. (1995), Biol Pharm Bull. 18: 1665–70.
Nakahata et al. (2008), Cell 134: 329–40.
Katada et al. (2010), Nat Struct Mol Biol. 17: 1414–21.
Gregoretti et al. (2004), J Mol Biol. 338: 17–31.